厄贝沙坦__(期刊论文)

厄贝沙坦电生理作用的实验研究

http://www.100md.com 《第四军医大学学报》 2005年第1期

厄贝沙坦,,厄贝沙坦；心肌；钙通道；膜片钳术；电生理学,0引言,1材料和方法,2结果,3讨论

     Electrophysiology of Irbesartan in guinea pig ventricular myocytes

    YANG Jun, HUANG CongXin, JIANG Hong, WANG Teng

    Department of Cardiovasology, Peoples Hospital, Wuhan University, Wuhan 430060, China

    【Abstract】 AIM: To investigate the effects of Irbesartan on ICaL, IK1, INa and transmembrane action potentials in guinea pig ventricular myocytes. METHODS： Membrane currents were recorded with patch clamp technique in a wholecell clamp configuration. RESULTS： ① Irbesartan (10，100，1000 nmol/L) reduced the ICaL density (PA/PF) from (-98±11) (control) to (-67±09), (-42±08) and (-21±0.4) (n=5, P<005 or 001) respectively in a concentrationdependent manner. ② Irbesartan upshifted the currentvoltage (IV) curve, but the characteristics of IV relationship were not significantly altered by Irbesartan. ③ Irbesartan blocked ICaL in a usedependent manner. ④ Steadystate activation curve of ICaL was not affected markedly, but Irbesartan (100 nmol/L) markedly shifted the steadystate inactivation curve of ICaL to the left, and accelerated the voltagedependent inactivation of calcium current, V1/2 value was (-30±5) mV in the control and (-39±7) mV in the presence of Irbesartan, the κ value was (82±07) and (116±13) respectively (n=5 ......

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