Multicenter clinical trial on injection of cefotaxime sodium and sulbactam sodium in prevention and treatment of bacterial infections in obstetrics and gynecology

    LU Linª²Yuan, DENG Kunª²Yi, WAN Bo

    1Department of Obstetrics and Gynecology, 2Department of Clinical Laboratory, Bo¬ðai Hospital, Zhongshan 528400, China

    ¡¾Abstract¡¿ AIM: To evaluate the clinical efficacy, safety and adverse drug reaction of cefotaxime sodium and sulbactam sodium in the prevention and treatment of bacterial infections in obstetrics and gynecology. METHODS: A randomized controlled multicenter clinical trial on the efficacy and safety of Chinaª²made cefotaxime sodium and sulbactam sodium at 1.5 g every 12 h (mild), 3.0 g every 12 h (moderate) and 3.0 g every 8 h (serious) was conducted to prevent or treat bacterial infections. RESULTS: The curative rate (80.8%) in the test group increased significantly (P<0.05) compared with that of control group (75.2%), while no significant differences were found in the efficacy rate (95.5% vs 94.1% ) and the bacterial clearance rate ( 96.4% vs 95.2%) between the 2 groups (P>0.05). There was no serious adverse drug reactions to cefotaxime sodium and sulbactam sodium in the clinical trial. CONCLUSION: The injection of cefotaxime sodium and sulbactam sodium is effective and safe for the prevention and treatment of bacterial infections in obstetrics and gynecology. ......