【摘 要】 目的 比较β2 受体激动剂福莫特罗，沙美特罗和沙丁胺醇扩张支气管的效应。 方法 10名轻中度哮喘患者3天内分别吸入福莫特罗(9μg)、沙美特罗(50μg)和沙丁胺醇(200μg)，比较给药前及给药后各时点的1s用力呼气量(FEV 1 )。 结果 吸入福莫特罗和沙丁胺醇5min后即引起FEV 1 显著增加，而吸入沙美特罗则需15min后方引起FEV1 显著增加;吸入福莫特罗及沙美特罗12h后仍可改善FEV1 ，FEV1 改善率分别为17%和16%。 结论 福莫特罗既可作为长效的支气管扩张剂预防和治疗哮喘发作，又可应用于哮喘患者急性发作时迅速控制症状，兼具沙丁胺醇及沙美特罗的优点。

    【关键词】 支气管哮喘;福莫特罗;沙美特罗;沙丁胺醇;对比研究

    Comparison of bronchodilating effects of formoterol，salmeterol and salbutamol MA Zhen，WANG Hai-lan，ZHOU Lu-qiu.(Longgang Central Hospital of Shenzhen，Guangdong518116，China)

    【Abstract】 Objective To compare the bronchodilating effects of inhaled formoterol，salmeterol and salbutamol.Methods Ten patients with mild or moderate asthma underwent a three-day trial.FEV 1 at baseline and at every time-point after inhalation were recorded.Results Formoterol and salbutamol produced significant and rapid increases in FEV 1 within5min after inhalation but salmeterol exerted a slower bronchedilating action ......