肝癌组织IGF-Ⅱ表达与HBV DNA复制及病理学特征的关系
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邱历伟, 姚登福, 吴信华, 吴 玮, 苏小琴,
肝细胞癌;胰岛素样生长因子;免疫组织化学;HBVDNA,肝癌组织IGF-Ⅱ表达与HBVDNA复制及病理学特征的关系,邱历伟,姚登福,吴信华,吴玮,苏小琴,邹黎,邱历伟,通讯作者,Correlation
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邱历伟, 姚登福, 吴信华, 吴玮, 苏小琴, 邹黎, 南通大学附属医院临床分子生物学中心 江苏省南通市 226001
邱历伟, 南通大学肿瘤学硕士生, 主要从事肿瘤早期诊断及分子机制研究.
江苏省卫生厅项目, No. H200523
南通市社会发展科技计划, No. S5053
通讯作者: 姚登福, 226001, 江苏省南通市, 南通大学附属医院临床分子生物学中心. yaodf@ahnmc.com
收稿日期: 2006-03-03 接受日期: 2006-03-11
Correlations of insulin-like growth factor-II expression with hepatitis B virus DNA replication and clinical pathological characteristics in human hepatocelullar carcinoma
Li-Wei Qiu, Deng-Fu Yao, Xin-Hua Wu, Wei Wu, Xiao-Qin Su, Li Zou
Li-Wei Qiu, Deng-Fu Yao, Xin-Hua Wu, Wei Wu, Xiao-Qin Su, Li Zou, Research Center of Clinical Molecular Biology, the Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Supported by the Grants from the Medical Science Project of Health Department of Jiangsu Province, No. H200523, and the Science and Technology Project for Social Development of Nantong, China, No. S5053
Correspondence to: Professor Deng-Fu Yao, Research Center of Clinical Molecular Biology, the Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com
Received: 2006-03-03 Accepted: 2006-03-11
Abstract
AIM: To investigate the expression of insulin-like growth factor-II (IGF-II) in hepatocellular carcinoma (HCC) as well as its correlations with the pathogenesis, development and prognosis of HCC.
METHODS: IGF-II expression was detected by immunohistochemistry in 30 HCC and their corresponding non-cancerous tissues. Liver HBV DNA was detected by in situ molecular hybridization technique and the relationship was analyzed between IGF-II expression and HBV replication or the clinical pathological characteristics.
RESULTS: The stronger expression of IGF-II was found in liver cancer tissues. The positive rate of IGF-II expression was 83.3% in HCC, and 46.7% in non-cancerous liver tissues (P < 0 ......
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