复方甘草酸苷对暴发性肝衰竭患者的保护作用
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于仲青, 杨宝山, 王 岩, 陈立艳, 毕蔓茹,
甘草酸苷;暴发性肝衰竭;炎症介质;病情转归,于仲青,杨宝山,王岩,陈立艳,毕蔓茹,王福祥,马英骥,通讯作者,ProtectiveeffectofStronge
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于仲青, 杨宝山, 王岩, 陈立艳, 毕蔓茹, 王福祥, 马英骥, 哈尔滨医科大学第一临床医学院传染科 黑龙江省哈尔滨市 150001
黑龙江省十五攻关重大课题, No. 200101031-00
通讯作者: 杨宝山, 150001, 黑龙江省哈尔滨市, 哈尔滨医科大学第一临床医学院传染科. baoshanyang@126.com
电话: 0451-53601171
收稿日期: 2006-01-03 接受日期: 2006-01-25
Protective effect of Stronger Neo-Minophagen C on patients with fulminant liver failure
Zhong-Qing Yu, Bao-Shan Yang, Yan Wang, Li-Yan Chen, Man-Ru Bi, Fu-Xiang Wang, Ying-Ji Ma
Zhong-Qing Yu, Bao-Shan Yang, Yan Wang, Li-Yan Chen, Man-Ru Bi, Fu-Xiang Wang, Ying-Ji Ma, Department of Infectious Diseases, the First Clinical Medical College of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Supported by the Key Program during the 10th Five-Year Plan of Heilongjiang Province, No.200101031-00
Correspondence to: Bao-Shan Yang, Department of Infectious Diseases, the First Clinical Medical College of Harbin Medical University, Harbin 150001, Heilongjiang Province, China. baoshanyang@126.com
Received: 2006-01-03 Accepted: 2006-01-25
Abstract
AIM: To discuss the protective effect of Stronger Neo-Minophagen C (SNMC) on patients with fulminant liver failure (FLF).
METHODS: From March 2003 to March 2005, 86 FLF patients were selected for this study, and they were assigned into group A and B. The patients in group A were intravenously injected with SNMC 120 mL per day, combined with symptomatic treatment to protect the liver. Symptomatic treatment was only performed on patients in group B, serving as controls. The level changes of serum alanine aminotransferase (ALT), cholesterol (CHOL), total bilirubin (TBIL), prothrombin activity (PTA), tumor necrosis factor TNF-α, nitrix oxide (NO), and interleukin-6 (IL-6), as well as the outcome of the disease, were observed and comparatively analyzed.
RESULTS: The levels of ALT and TBIL had no significant difference between the two groups (P > 0 ......
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