罗格列酮治疗非乙醇性脂肪肝的疗效与脂联素相关
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崔克勤, 赵翔伟, 张 耀, 康小红, 孟 杰,
罗格列酮;非乙醇性脂肪肝;胰岛素抵抗;脂联素;疗效,崔克勤,赵翔伟,张耀,康小红,孟杰,陈贤栎,通讯作者,Efficacyofrosiglitazonei
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崔克勤, 赵翔伟, 张耀, 康小红, 孟杰, 陈贤栎, 河北大学附属医院内分泌科 河北省保定市 071000
通讯作者: 崔克勤, 071000, 河北省保定市红星路108号, 河北大学附属医院内分泌科. ckqmjpmqb@126.com
电话: 0312-5981512
收稿日期: 2006-02-17 接受日期: 2006-03-21
Efficacy of rosiglitazone in treatment of nonalcoholic fatty liver disease and its relations with adiponectin
Ke-Qin Cui, Xiang-Wei Zhao, Yao Zhang, Xiao-Hong Kang, Jie Meng, Xian-Li Chen
Ke-Qin Cui, Xiang-Wei Zhao, Yao Zhang, Xiao-Hong Kang, Jie Meng, Xian-Li Chen, Department of Endocrinology, the Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China
Correspondence to: Ke-Qin Cui, Department of Endocrinology, the Affiliated Hospital of Hebei University, 108 Hongxing Road, Baoding 071000, Hebei Province, China. ckqmjpmqb@126.com
Received: 2006-02-17 Accepted: 2006-03-21
Abstract
AIM: To explore an effective, safe and convenient method in the treatment of nonalcoholic fatty liver disease (NAFLD) and a marker in the pre-diction of the efficacy.
METHODS: One hundred and twenty-four patients diagnosed with NAFLD (except cirrhosis) were randomly divided into rosiglitazone (RSG) treatment group and placebo group (controls). After treatment with the corresponding methods, comparative analysis on the efficacy and serum adiponectin was performed between the two groups.
RESULTS: ESG significantly improved the liver function, levels of blood glucose, lipid and serum adiponectin, as well as insulin resistance (HOMA-IR) (P < 0.05). The total effective rates were markedly significantly between RSG group and placebo group (57/63 vs 37/61, P < 0.01). The levels of serum alanine aminotransferase (ALT) was significantly correlated with adiponectin level (r = -0.685, P < 0.01) and HOMA-IR (r = 0.447, P < 0.01). The safety was not notably different between the two groups (P > 0.05).
CONCLUSION: RSG is effective and safe in the treatment of NAFLD and serum adiponectin level can be used to predict its efficacy ......
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