胃癌及癌前病变中P27和Cyclin E蛋白的表达意义
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孔 郁, 朴熙绪, 张 媛, 朴东明
胃癌;P27;CyclinE;免疫组织化学,胃癌及癌前病变中P27和CyclinE蛋白的表达意义,孔郁,朴熙绪,张媛,朴东明,孔郁,通讯作者,ExpressionandsignificancesofP
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孔郁, 朴熙绪, 张媛, 延边大学医院消化内科 吉林省延吉市 133000
朴东明, 延边大学医院病理科 吉林省延吉市 133000
孔郁, 2003年延边大学医学院内科学硕士, 主要从事胃癌分子病理学研究.
通讯作者: 朴熙绪, 133000, 吉林省延吉市局子街119号, 延边大学医院消化内科. piaoxixu1951@yahoo.com.cn
电话: 0433-2660061 传真: 0433-2513610
收稿日期: 2006-02-27 接受日期: 2006-03-11
Expression and significances of P27 and Cyclin E protein in gastric carcinoma and precancerous lesion
Yu Kong, Xi-Xu Piao, Yuan Zhang, Dong-Ming Piao
Yu Kong, Xi-Xu Piao, Yuan Zhang, Department of Gastroenterology, the Affiliated Hospital of Yanbian University, Yanji 133000, Jilin Province, China
Dong-Ming Piao, Department of Pathology, the Affiliated Hospital of Yanbian University, Yanji 133000, Jilin province, China
Correspondence to: Xi-Xu Piao, Department of Gastroenterology, the Affiliated Hospital of Yanbian University, 119 Juzi Street, Yanji 133000, Jilin province, China. piaoxixu1951@yahoo.com.cn
Received: 2006-02-27 Accepted: 2006-03-11
Abstract
AIM: To investigate the expression of P27 and Cyclin E protein in gastric carcinoma (GC) and precancerous lesion and their correlations with the clinicopathological parameters.
METHODS: Immunohistochemical staining was used to evaluate the expression of P27 and Cyclin E protein in the samples of normal gastric mucosa (NGM, n = 20), chronic superficial gastritis (CSG, n = 20), chronic atrophic gastritis (CAG) with metaplasia (n = 20), CAG with dysplasia (n = 20) and GC (n = 60), and their correlations with the clinicopathological parameters were analyzed.
RESULTS: The positive rates of P27 and Cyclin E protein expression were 100% and 5% in NGM, 85% and 10% in CSG, 70% and 20% in CAG with metaplasia, 45% and 30% in CAG with dysplasia, and 38.3%(23/60) and 40%(24/60) in GC, respectively. The positive rate of P27 expression in GC and CAG with dysplasia were lower than that in NGM, CSG, and CAG with metaplasia (P < 0 ......
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