蒙、汉族人群小肠脂肪酸结合蛋白基因Ala54Thr多态性的频率
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王振辉, 常晓彤, 侯小平, 董明纲, 王洪涛,
IFABP基因;单核苷酸多态性;高脂饮食;蒙古族;汉族,王振辉,侯小平,王洪涛,张利,李桂喜,常晓彤,董明纲,王振辉,通讯作者,Inve
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王振辉, 侯小平, 王洪涛, 张利, 李桂喜, 中国人民解放军第251医院检验科 河北省张家口市 075000
常晓彤, 董明纲, 河北北方学院生物化学教研室 河北省张家口市 075000
王振辉, 1992年张家口医学院本科毕业, 2002年第三军医大学硕士, 检验医师, 主要从事代谢综合征方面的研究.
通讯作者: 王振辉, 075000, 河北省张家口市建国路13号, 解放军第251医院检验科. wangzh680927@sina.com
电话: 0313-8785616
收稿日期: 2006-03-02 接受日期: 2006-03-21
Investigation of Ala54Thr polymorphism in intestinal fatty acid binding protein in Han and Mongoloid populations
Zhen-Hui Wang, Xiao-Tong Chang, Xiao-Ping Hou, Ming-Gang Dong, Hong-Tao Wang, Li Zhang, Gui-Xi Li
Zhen-Hui Wang, Xiao-Ping Hou, Hong-Tao Wang, Li Zhang, Gui-Xi Li, Department of Clinical Laboratory, the 251st Hospital of Chinese PLA, Zhangjiakou 075000, Hebei Province, China
Xiao-Tong Chang, Ming-Gang Dong, Department of Biochemistry, Hebei North University, Zhangjiakou 075000, Hebei Province, China
Correspondence to: Zhen-Hui Wang, Department of Clinical Laboratory, the 251st Hospital of Chinese PLA, 13 Jianguo Avenue, Zhangjiakou 075000, Hebei Province, China. wangzh680927@sina.com
Received: 2006-03-02 Accepted: 2006-03-21
Abstract
AIM: To investigate the single nucleotide polymorphism (SNP) at the 54Ala/Thr (A/T) in the intestinal fatty acid binding protein (IFABP) gene in Hans and Mongolians.
METHODS: Polymerase chain reaction (PCR), restriction endonuclease (HhaI) digestion and DNA sequencing technique were performed to detect the IFABP gene polymorphism at the 54Ala/Thr in 208 Mongolians of pastoral area, 150 Mongolians of Zhangjakou city and 190 Hans.
RESULTS: The allelic frequency of 54Thr was 0.51, 0.33, and 0.30, while that of 54Ala was 0.49, 0.67, and 0.70 in Mongolians of pastoral area, Zhangjakou city and 190 Hans, respectively. In comparison with that of Mongolians in urban area and Hans, the allelic frequency of codon 54Thr in Mongolians of pastoral area was significantly increased (χ2 = 22 ......
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