大肠埃希菌__(期刊论文)

泌尿系感染产超广谱β内酰胺酶(ESBLs)大肠埃希菌的耐药表型和基因分型

http://www.100md.com 《第四军医大学学报》 2005年第7期

大肠埃希菌,,大肠埃希菌；超广谱β内酰胺酶；表型,耐药；基因分型,1材料和方法,2结果,3讨论,【参考文献】

     Resistant phenotype and genotype of extended spectrum βlactamase (ESBLs) produced in Escherichia coli isolated from urinary infections

    GENG Yan1, ZHANG WangGang1, WANG XiangLing1, YANG HuiBin2, HUANG Fang1, ZHANG Yi1

    1Department of Clinical Laboratory, Second Hospital, Xian Jiaotong University, Xian 710004, China, 2Department of Transportation Management of Xian City, Xian 710065, China

    【Abstract】 AIM: To study the resistant phenotype and genotype of extended spectrum βlactamase (ESBLs) produced in Escherichia coli isolated from urinary infections. METHODS: Organisms of clinical infection were identified by automatic microbial system (Vitek) and the bacterial susceptibility was tested by KirbyBauer (KB) method as described in NCCLS. ESBLs was detected by disk diffusion confirmatory test and CTXM or SHV specific PCR were used to determine the genotype of ESBLs. RESULTS: 24.0% of E.coli produced ESBLs. Fortytwo of the 62 ESBLs producing strains (67.7%) expressed CTXM βlactamase and 9 of the 62 ESBLs producing strains (14.5%) expressed SHV βlactamase. CONCLUSION: ESBLs producers are mainly resistant to cefotaxime and cefiriaxone and most of them are multidrug resistant. Cefotaxime resistance is partially due to the production of CTXM βlactmase. CTXM βlactmase is most prevalent. ......

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