Pharmacokinetics of pazufloxacin mesylate injections in healthy volunteers

    XIE Li1, WEN Aiª²Dong1, LUO Xiaoª²Xing2, WU Yin1, YANG Zhiª²Fu1, CHEN Pinª²Jun1, ZHAO Lei1, LI Wei1

    1Department of Pharmacy, Xijing Hospital, 2Department of Pharmacology, School of Basic Medicine, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To study the pharmacokinetic characteristics of pazufloxacin mesylate in healthy volunteers. METHODS: Ten healthy volunteers received a single dose of 300 mg of pazufloxacin mesylate by intravenous injection. The plasma concentrations of pazufloxacin mesylate were determined by HPLC method. RESULTS: The concentrationª²time curve after administration was best fitted to twoª²compartments open model. The main pharmacokinetics parameters of pazufloxacin mesylate were as follows: Tmax, ¦Ñmax, T1/2¦Â, AUC(0-8) were (0.52¡À0.17) h, (6.63¡À1.86) mg/L, (1.90¡À0.24) h, and (13.42¡À2.96) h¡¤mg/L, respectively. CONCLUSION: Pharmacokinetic study shows that pazufloxacin mesylate has short halfª²life and high concentration in plasma. Effective concentration by intravenous injection can be achieved after two or three dose of 300 mg pazufloxacin mesylate per day. ......