Effect of perindopril with spironolactone on left ventricular remodeling of senile degenerative valvular heart disease

    ZHANG Junª²Song,WANG Ling,DENG Jieª²Xi,LU Wuª²Sheng,CHEN Jinª²Song,DOU Yan,LIN Gengª²Hai

    Department of Aged Cardiovasology,PLA 175th Hospital,Zhangzhou 363000,China

    ¡¾Abstract¡¿AIM: To observe the effect of perindopril and spironolactone on the left ventricular remodeling of senile degenerative valvular heart disease (SDVHD).METHODS: One hundred and sixtyª²eight cases of SDVHD with congestive heart failure (CHF)were randomly divided into two groups: the control group (n=80) and the therapy group (n=88).The control group was treated regularly and the therapy group was additionally treated with perindopril (2~8 mg/d) and spironolactone (20 mg/d).The followª²up period was(9¡À3 )months.Left ventricular volume (LVV),left ventricular wall volume (LVWV),left ventricular wall volume (LVCV)and left ventricular mass (LVM) were determined by color Doppler ultrasonography before and after the test and the results were analyzed.RESULTS: The clinical effect of the therapy group was better than that of the control group(P<0.05).The LVV,LVWV,LVCV and LVM of the therapy group significantly decreased after the test(P<0ª±01)while only LVV and LVCV significantly decreased in the control group(P<0ª±01).After the test,LVV,LVWV and LVCV of the therapy group were significantly different between the two groups.CONCLUSION: Combined use of perindopril and spironolactone is a good choice for left ventricular remodeling of SDVHD. ......