【摘要】 目的：观察长春瑞滨(NVB)加顺铂(DDP)联合化疗，治疗晚期非小细胞肺癌(NSCLC)的临床效果。方法： 选择非小细胞肺癌58例，男42例、女16例，方案NVB 25 mg/m2，静滴d 1-8，DDP 20 mg/m2d 1-5静滴。结果：PR 28例、NC 27例、PD 3例，总有效率48.27%。主要毒副作用为骨髓抑制白细胞下降占81.03%，其中Ⅲ-Ⅳ白细胞下降率为36.21%，消化道反应发生率53.44%，大多数较轻，局部疼痛或静脉炎的发生率27.58%。结论：长春瑞滨(NVB)加顺铂联合化疗治疗晚期NSCLC有效率高，毒性反应可以耐受，值得临床研究应用。

    【关键词 】 长春瑞滨；顺铂；非小细胞肺癌

    Homemade vinorelbine based combination chemotherapy in non-small-call lung cancer

    SONG Shi-jun, SHEN Jia-hui

    (Henan First Rongkang Hospital, Xinxiang 453003,China)

    【Abstract】 Objective：To evaluate the results of combination chemotherapy with vinorelbine (NVB) plus cisplatin (DDP) in the treatment of non-small-cell lung cancer (NSCLC). Methods:fifty-eight patients with advanced NSCLC were enrolled in this study. Adenocarcinoma was the most common type of malignancy.Results: The overall rate was 48.27%. The does limiting toxicity was neutropenia, which was seen 81.03% in treated cases. The local venous toxicity was observed in 27.58% of the patients. Conclusions: A high response rate was obtained in advanced NSCLC treated by NVB plus DDP. NVB is a promising antitumor agent with tolerable toxicity. ......