Effect of lipoteichoic acid of bifidobacterium on liver and bone marrow of aging mice

    WANG Yue,FU Yuª²Rong,CHEN Shuª²Hui,LIU Mingª²Fang

    Department of Clinical Microbiology,Chongqing University of Medical Sciences,Chongqing 400016,China

    ¡¾Abstract¡¿ AIM: To study the effect of lipoteichoic acid (LTA) of bifidobacterium on liver and bone marrow in aging mice and to explore its mechanism.METHODS: Aging mice were induced by sc Dª² galactose and LTA was simultaneously given ip to them daily,and for 40 days.The body mass,liver index,liver morphology,the expression of p16,cª²fos protein and micronucleus frequency in the bone marrow were tested by Gimesa staining,SABC technique of immunohistochemistry and other methods.RESULTS: Compared with those in the young control group,the body mass and the expression of cª²fos protein in liver noticeably reduced in aging model mice(P<0.05)while the expression of p16 protein in liver and micronucleus frequency in the bone marrow remarkably increased (P<0.05).After administrating LTA to aging model mice,all the above mentioned changes were reversed(P<0.05).CONCLUSION: LTA of bifidobacterium has an effect of deferring senescence of liver and bone marrow in aging model mice. ......