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经导管肝动脉化疗栓塞联合局部注射无水乙醇治疗中晚期原发性肝癌
http://www.100md.com 《中华现代影像学杂志》 2000年第3期
无水乙醇,,无水乙醇;原发性肝癌;经导管肝动脉化疗栓塞,1资料与方法,2结果,3讨论,【参考文献】
     【摘要】 目的 探讨经导管肝动脉化疗栓塞(TACE)联合经皮注射无水乙醇(PEI)治疗中晚期原发性肝癌的治疗效果。方法 非随机对照研究,纳入90例中晚期原发性肝癌。41例接受TACE联合PEI治疗(治疗组),另49例仅接受TACE治疗(对照组)。全部患者随访12个月,观察安全性、局部治疗效果及生存时间。结果 治疗组患者共接受99次TACE、131次PEI治疗,对照组共接受116次TACE治疗。全部患者均无严重并发症出现,治疗组总有效率(CR+PR)高于对照组,分别是58.5%和28.6%(P<0.05)。治疗组3、6、12个月生存率及生存曲线均高于对照组(P=0.0002),两组生存率分别为88.19%、75.03%、44.30%和62.12%、36.48%、21.02%,两组差异有显著性(P<0.05)。结论 本文研究结果提示经导管肝动脉化疗栓塞联合经皮注射无水乙醇治疗安全有效,提高了中晚期原发性肝癌的局部治疗效果,延长了患者的生存时间。

    【关键词】 无水乙醇;原发性肝癌;经导管肝动脉化疗栓塞

    Transcatheter hepatic arterial chemoembolization in combination with percutaneous ethanol injection in patients with advanced primary hepatocellular carcinoma

    LIU Yuan,GUAN Yongsong,HE Qing,et al.

    Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China

    【Abstract】 Objective To evaluate the safety and efficacy of percutaneous ethanol injection (PEI) for the treatment of patients with advanced hepatocellular carcinoma (HCC) in combination with transcatheter hepatic arterial chemoembolization (TACE).Methods A total of 90 patients with advanced HCC were enrolled in a nonrandomized clinical trial.Of which,49 were treated only by transcatheter hepatic arterial chemoembolization (control group) while the other 41 received a combination treatment of TACE and PEI (treatment group).Patients were followed up for 12 months and the safety,therapeutic effects and survival time were evaluated and analysed statistically.Results A total of 116 procedures of TACE in control group,131 procedures of PEI and 99 procedures of TACE in treatment group were performed respectively.No serious complication was identified.The total effective rates (CR+PR) of the treatment group and the control group were 58.5% and 28.6% respectively (P<0.05).The survival rates at 3 months (mo),6 mo and 12 mo were 88.19%,75.03% and 44.30% in the treatment group and 62.12%,36.48% and 21.02% in the control group,respectively,which suggested significantly better survival rates in the treatment group compared to the control group (P=0.0002).Conclusion The data from this clinical trial suggest that the combination treatment of PEI and TACE is safe and feasible and can improve local antitumor efficacy and survival time for patients with advanced HCC. ......

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