Effects and mechanism of total flavones of buckwheat leaf in lowering serum glucose and lipid

    LIU Shuª²Mei, HAN Shuª²Ying, CUI Guoª²Jin, ZHU Liª²Sha, L¦a Hua

    Department of Pharmacology, North China Coal Medical College, Tangshan 063000, China

    ¡¾Abstract¡¿ AIM: To study the effects and mechanism of total flavones of buckwheat leaf (TFBL) in lowering serum glucose, lipid and antiª²lipid peroxidation in diabetic and hyperlipidemia rats. METHODS: The diabetic and hyperlipid model of rats were established by streptozotocin and high lipid feed. The levels of serum glucose, TC, TG, insulin, MDA, SOD and insulin receptor of liver were detected after TFBL was administered orally with the dose of 0.2, 0.4 and 0.8 g¡¤kg-1 for 12 wk. RESULTS: TFBL obviously decreased the serum glucose, TG and LDLª²c (P<0.01), increased HDLª²c (P<0.01), enhanced both the insulin sensitivity index and the combination of insulin with receptor, and improved the glucose tolerance. TFBL also obviously lowered the content of MDA (P<0.01) and improved the SOD activity in blood. CONCLUSION: TFBL has the effects of reducing serum glucose, lipid, MDA, antiª²lipid peroxidation and increasing the insulin receptor quantity and/or sensitivity. ......