参芪降糖颗粒__(期刊论文)

参芪降糖颗粒对实验性糖尿病大鼠胰岛β细胞、C肽及血浆胰岛素释放的影响

http://www.100md.com 《第四军医大学学报》 2005年第19期

参芪降糖颗粒,,参芪降糖颗粒；糖尿病；链脲霉素；胰岛β细胞；C肽；胰岛素,1材料和方法,2结果,3讨论,【参考文献】

     Effect of ginsengmilkvetch declining sugar granule on islet β cells, peptide C and the release of insulin in diabetic rat

    DI Ling1, LI YingQian2, ZHANG Wei3

    1Department of Combination of Chinese Medicine and Western Medicine, Second Hospital, Xi’an Jiaotong University, Xi’an 710004, China, 2Department of Pharmacology, Medical School, Xi’an Jiaotong University, Xi’an 710061, China, 3Clinic of the Second Artillery Engineering Institute, Xi’an 710025, China

    【Abstract】 AIM: To study the effect of ginsengmilkvetch declining sugar granule (GMDSG) on islet β cells, peptide C and the release of insulin in diabetic rats, and to investigate the mechanism of declining blood glucose. METHODS: The diabetic rats were formed with injection of streptozotocin (STZ). We studied the effect of GMDSG by determining blood glucose, peptide C and insulin. The ultrastructure of islet β cells was also observed. RESULTS: After treatment with GMDSG (2.0 g·kg-1), fasting blood glucose of the diabetic rats was decreased gradually while peptide C and serum insulin were increased. Besides, GMDSG exerted obvious protective effect on islet β cells in diabetic rats. CONCLUSION: GMDSG exerts a good therapeutic effect on high blood glucose in diabetic rats and its mechanism may be related to the protective effect on islet β cells, thereby increase the insulin secretion. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/05/08/97/37/32.htm

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