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不明原因早期自然流产蜕膜组织中肿瘤坏死因子受体1的表达
http://www.100md.com 《第四军医大学学报》 2005年第19期
早期妊娠,,早期妊娠;流产;蜕膜;肿瘤坏死因子;受体,1对象和方法,2结果,3讨论,【参考文献】
     Expression of tumor necrosis factor receptor 1 in deciduas from unexplained early spontaneous abortion

    YAN ChunFang1, JIN Hui1, LI Xu2, CHEN Wei2, YU XueWen1, ZHANG YunJin1

    1Center of Maternal and Child Health Care, 2Center of Experimental Medicine, First Hospital, Xi’an Jiaotong University, Xi’an 710061, China

    【Abstract】 AIM: To investigate the expression and histological localization of tumor necrosis factor receptor 1 (TNFR1) in deciduas of unexplained early spontaneous abortion. METHODS: Thirtyone women, who had unexplained spontaneous abortion at 6-10 weeks of gestational period, were used as abortion group. The control group consisted of 30 normal pregnancy women who preferred artificial abortion at 6-10 weeks gestational period. Decidua samples from the two groups were obtained at the time of abortion. Immunohitochemisty was used to determine the location and intensity of TNFR1 staining in all the deciduas. RESULTS: The rates of TNFR1 expressed in decidual glandular epithelia cells, stromal cells and blood vessel endothelial cells of abortion group were 77.4%, 93.5% and 67.7% respectively, and in the control group were 96.7%, 70.0% and 23.3% respectively. There was no significant difference of TNFR1 expressive rate in the decidual glandular epithelia cells between the two groups (P=0.0529), but the expressive rate of TNFR1 in the decidual stromal cells and blood vessel endothelia cells from the abortion group was higher than that from the control group (P=0.0217, P=0.0008). The expressive intensity of TNFR1 was weaker in the decidual glandual epithelial cells from the abortion group than that from the control group (P<0.01), but the expressive intensity of TNFR1 in the decidual stromal cells from abortion group was stronger than that from control group (P<0.01); there was no significant difference of TNFR1 expressive intensity in blood vessel endothelia cells between the two groups. CONCLUSION: The increase of TNFR1 expressed in the decidual stromal cells and blood vessel endothelial cells, and the decrease of TNFR1 expressed in the decidual glandual epithelial cells may contribute to the unexplained early spontaneous abortion. ......

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