A型肉毒毒素腹腔注射对大鼠小肠通过速度及胆碱酯酶和P物质表达的影响
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韩 辉, 刘庆森, 刘文徽
A型肉毒毒素;小肠通过速度;胆碱酯酶;P物质;大鼠韩辉,刘庆森,刘文徽.A型肉毒毒素腹腔注射对大鼠小肠通过速度及胆碱酯酶和P物质表达的影响. 世界华人消化杂志2006;14(14)1412
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韩辉, 解放军总医院急诊科 北京市 100853
刘庆森, 刘文徽, 解放军总医院消化科 北京市 100853
通讯作者: 韩辉, 100853, 北京市海淀区复兴路28号, 解放军总医院急诊科. hanh301@163.com
电话: 010-66936224
收稿日期: 2006-03-09 接受日期: 2006-04-06
Effects of intraperitoneal injection of botulinum toxin A on passage velocity in small intestine and expression of acetylcholinesterase and substance P in rats
Hui Han, Qing-Sen Liu, Wen-Hui Liu
Hui Han, Department of Emergency, General Hospital of Chinese PLA, Beijing 100853, China
Qing-Sen Liu, Wen-Hui Liu, Department of Gastroenterology, General Hospital of Chinese PLA, Beijing 100853, China
Correspondence to: Hui Han, Department of Emergency, General Hospital of Chinese PLA, Beijing 100853,China. hanh301@163.com
Received: 2006-03-09 Accepted: 2006-04-06
Abstract
AIM: To investigate the effects on small intestinal passage velocity and expression of acetylcholinesterase (AChE) and substance P in rats by injection of botulinum toxin A (BTA) intraperitoneally.
METHODS: Twenty-four Wistar rats of 8 weeks were randomly and averagely divided into 4 groups. The rats in group A, B and C were intraperitoneally injected with 4, 2, and 1 U BTA containing in 2 mL normal saline, while those in group D were treatment with the same amount of normal saline (2 mL). Charcoal suspension pushing test of small intestine and immunohistochemistry of AChE and Substance P in the end ileum were performed 4 wk after injection.
RESULTS: The propelling rate of charcoal suspension at the end of 4 weeks in small intestine was significantly lower in group A (53 ......
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