慢性乙型肝炎病毒感染免疫耐受期患者的临床病理特征
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邢汉前, 辛绍杰, 张 欣, 陈黎明, 赵景民,
慢性HBV感染;免疫耐受;肝组织病理邢汉前,辛绍杰,张欣,陈黎明,赵景民,游绍莉,赵军,王岩.慢性乙型肝炎病毒感染免疫耐受期患者的临床病理特征. 世界华人消化杂志2006;14(14)14
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邢汉前, 辛绍杰, 陈黎明, 赵景民, 游绍莉, 赵军, 王岩, 解放军第302医院感染三科 北京市 100039
张欣, 首都医科大学附属佑安医院临床检验中心 北京市 100054
通讯作者: 辛绍杰, 100039, 北京市, 解放军第302医院感染三科.
电话: 010-66933129-6023
收稿日期: 2006-02-25 接受日期: 2006-03-15
Clinical status and hepatic pathology of patients with chronic hepatitis B virus infection in immune tolerant phase
Han-Qian Xing, Shao-Jie Xin, Xin Zhang, Li-Ming Chen, Jing-Min Zhao, Shao-Li You, Jun Zhao, Yan Wang
Han-Qian Xing, Shao-Jie Xin, Li-Ming Chen, Jing-Min Zhao, Shao-Li You, Jun Zhao, Yan Wang, the Third Department of Infectious Deseases, the 302nd Hosptal of Chinese PLA, Beijing 100039, China
Xin Zhang, Center of Clinical Laboraotry, the Affilated Youan Hospital of Capital Medical University, Beijing 100054, China
Correspondence to: Shao-Jie Xin, the Third Department of Infectious Deseases, the 302nd Hosptal of Chinese PLA, Beijing 100039, China
Received: 2006-02-25 Accepted: 2006-03-15
Abstract
AIM: To investigate the characteristics of the clinical status and hepatic pathology of patients with hepatitis B virus (HBV) infection in immune tolerant phase.
METHODS: Three hundred and eighty patients with chronic HBV infection of different phases were involved in this study. The data about the ages of patients, vertival transmission, family history of HBV infection, hepatocytic expression of HBsAg and HBCAg and hepatic pathology were statistically analyzed.
RESULTS: It was found that 61.8% of patients in immune tolerant stage were less than 16 years old, and 46.6% with a family history of HBV infection. Vertival transmission covered a percentage of 55% and in patients of immune tolerant stage. Of 89 patients in immune tolerant stage, the ratio of HBcAg expression was 78.7%. The ratios above were significantly higher than the corresponding ones in patients of immune active stage or non-active status (c2 = 38 ......
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