【摘要】 目的 讨论辛伐他汀对颈动脉粥样硬化的治疗及保护作用。方法 将48例稳定型心绞痛伴颈动脉粥样硬化及高脂血症患者随机分为对照组和治疗组,治疗组给予辛伐他汀20mg/d治疗,并在治疗后6个月以彩色超声多普勒检查双侧颈动脉、复查血脂及血浆高敏C反应蛋白,观察双侧颈动脉管腔内径及颈动脉后壁内膜中膜厚度,与对照组进行比较。结果 辛伐他汀治疗6个月后能有效降低血浆高敏C反应蛋白、总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平,升高高密度脂蛋白胆固醇水平,且双侧颈动脉管腔内径增大和内膜中膜厚度减小均有统计学意义(P<0.05或P<0.01)。结论 辛伐他汀能有效降低血脂及高敏C反应蛋白水平,在一定程度上对颈动脉粥样硬化斑块有改善作用。

    【关键词】 辛伐他汀;颈动脉粥样硬化;血脂;C反应蛋白

    The effect of simvastatin on carotid artery atherosclerosis

    FANG He-ying.The Ninth Hospital of Shanghai Jiaotong University,Shanghai 200065,China

    【Abstract】 Objective To discuss the curative effect and protection of simvastatin on carotid atherosclerosis.Methods 48 patients with stable angina, carotid atherosclerosis and hyperlipaemia were randomly divided into treatment group and control group.The treatment group were treated with simvastatin 20 mg/ d and their carotids, lipid level and CRP were checked after 6 months in order to compare with the control group on the carotid inner diameters(D),the thickness between carotid intima media thickness(IMT).Results 6 months' treatment with simvastatin can decrease total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)level in plasma efficiently,increase high density lipoprotein cholesterol(HDL-C)and the diminution of IMT all has statistical significance.Conclusion Simvastatin can decrease the lipid and CRP level in plasma efficiently,and to some extent,it can also improve and stabilize the carotid atheromanous plaque. ......