当前位置: 首页 > 期刊 > 《第四军医大学学报》 > 2005年第20期
编号:10975458
盐酸曲马多片人体药代动力学和生物等效性
http://www.100md.com 《第四军医大学学报》 2005年第20期
盐酸曲马多,,盐酸曲马多;药代动力学;生物利用度;色谱法,高压液相,1对象和方法,2结果,3讨论,【参考文献】
     Pharmacokinetics and relative bioequivalence of tramadol hydrochloride in healthy volunteers

    WANG Meng, WEN Ai Dong, ZHAO Lei, WU Yin, ZHANG San Qi, Li Hong Li,SHI Ru

    Department of pharmacy, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To compare the pharmacokinetic parameters and relative bioavailability of domestic and imported tramadol hydrochloride tablets so as to ensure quality of the medicine. METHODS: An open, randomized, two period crossover study with a two week washout interval was performed in 18 healthy volunteers. Concentrations of tramadol in serum were assayed by HPLC FR method. The pharmacokinetics parameters, AUC, Cmax and Tmax, were analyzed by two one side t test. RESULTS: The concentration time course after medication conformed to a 1 compartment open model with a first order absorption. The AUC(0 24 h), Cmax and Tmax of tramadol were (2173±680) and (2252±597) μg·h/L,(223±79) and (229±65)μg/L, (2.28±0.67) and (2.33±0.67)h respectively. The relative bioavailability of tramadol was 96.40%. CONCLUSION: Two tablets are bioequivalent. ......

您现在查看是摘要页,全文长 9946 字符