5_氟尿嘧啶壳聚糖微球的制备
5_氟尿嘧啶,,5_氟尿嘧啶;壳聚糖;微球,1材料与仪器,2方法与结果,3讨论,参考文献
摘要 本文报道了采用两种不同的方法制备5_Fu壳聚糖微球，微球A采用乳化交联法制备，微球B是首先制备成白蛋白微球，然后在其表面固定壳聚糖。研究了微球的一些基本特征，包括微球大小、形态与表面状态，结果表明微球A及微球B粒径主要分布在3.5～6.5 μm和0.6～28 μm范围内，药物含量分别为10.86%和8.52%，体外释放实验表明，在pH7.4磷酸盐缓冲溶液中，微球B具有显著的缓释作用，其释放特征符合Higuchi方程。关键词 5_氟尿嘧啶;壳聚糖;微球
5_fluorouracil_loaded Chitosan Microspheres
LIANG Gui_yuan,FANG Hua_feng,LIU Zhiwei
(College of Pharmacy, Tongji Medical University, Wuhan,P.R.China 430030)
Abstract Chitosan microspheres loaded with 5_Fu were prepared with two different methods. Microspheres A were prepared by cross_linking_emulsion method. Microspheres B were prepared by two steps：BSA microspheres were first made and then covered with chitosan. The size of the two kind of microspheres was about 3.5～6.5 μm and 06～2.8 μm respectively. The drug loading was about 10.86% and 8.52% respectively. 5_Fu release from microspheres B was sustained in phosphate buffer solution(pH 74) and it was ruled by Higuchi equation.
Key Words 5_fluorouracil;chitosan;microsphere
微球可在体内特异性分布 ......
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