【摘要】 目的 探讨肿瘤坏死因子(TNFα)在急性脑血管病致全身炎症反应综合征(SIRS)发病机制中的作用。方法 采用放射免疫分析方法检测69例单纯急性脑血管病患者和32例急性脑血管病致SIRS患者发病不同时期的血清TNFα含量及21例血库健康献血员的血清TNFα含量。结果 急性脑血管病致SIRS患者血清TNFα含量明显高于单纯急性脑血管病组及正常对照组(P<0.01)，且TNFα含量随病情好转而下降。结论 TNFα是急性脑血管病致SIRS发病中的主要炎性介质，它参与了机体的病理生理变化过程，它在急性脑血管病致SIRS的发病机制中起重要作用。

    【关键词】 肿瘤坏死因子；急性脑血管病；全身炎症反应综合征；作用机制

    The mechanism of TNFα on patients with SIRS caused by actlte cerebrovascular disease

    CUI Bao-wen,GUO Hong-zhi.

    The People’s Hospital of Yiyuan County,Shandong 256100,China

    【Abstract】 Objective To explore the mechanism of tumor necrosis factor-α(TNFα) on patients with systemic inflammatory response syndrome (SIRS) caused by acute cerebrovascular disease.Methods TNFα levels in 69 patients with acute cerebrovascular disease and 32 patients with SIRS caused by acute cerebrovascular disease and 21 controls were detected by radioimmunoassy.Results The TNFα serum levels of SIRS group caused by acute cerebrovascular disease were significantly higher than that of control and acute cerebrovascular disease group, the TNFα serum levels were lower with the control of disease.Conclusion TNFα is the main inflammatory intermediat or of SIRS caused by acute cerebrovascular disease.Which indicates it is involved in the pathophysiologic process.It play an important role in the active mechanism of SIRS caused by acute cerebrovascular disease. ......