http://www.100md.com 《第四军医大学学报》 2005年第20期
复方戊酸雌二醇,,复方戊酸雌二醇；绝经综合征,1对象和方法,2结果,3讨论,【参考文献】Clinical study of safety and efficacy of compound estradiolvalerate in women with menopause syndrome
HUANG YanHong1, XIN XiaoYan1, CHEN YaQiong1, CHEN BiLiang1, WANG DeTang1, ZHANG HongJU1, WEI Li1, LI GuiYun1,SHI Ru2
1Department of Obstetrics & Gynecology, 2Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xian 710033, Chian
【Abstract】 AIM: To evaluate the efficacy and safety of compound Estradiolvalerate in the treatment of menopause syndrome. METHODS: Fortyfive women with menopause syndrome were followed up in a randomized, doubleblind and selfmatched trial for 3 mo, and were divided into control group (Kliogest group) and treated group (compound estradiolvalerate group). The clinical efficacy was determined by Kupperman score. Serum levels of FSH, E2 were evaluated at baseline and in the 3 mo and the vital signs and laboratory data were measured. RESULTS: After 3 mo, Kupperman scores of the control group and the treated group decreased significantly by 96% and 97% respectively (P<0.01). The serum level of E2 increased (P<0.01) and reached the level of the late follicular phase ,while FSH decreased significantly (P<0.01). The side effects in the two groups were only breast swollen pain and vaginal bleeding. CONCLUSION: Compound estradiolvalerate was effective and safe in the improvement of menopause syndromes such as flushing and psychological symptoms, and it could be used in clinical perimenopause women. ......
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