关键词：严重急性呼吸道综合症；冠状病毒；抗体；血清学

    摘要：目的 明确是否存在症状轻微或无症状SARS冠状病毒感染者。 方法 以SARS冠状病毒全病毒裂解液作抗原，利用ELISA技术检测血清中SARS冠状病毒抗体，调查具有明显传染特征和呼吸道症状的SARS患者以及无明显临床症状表现的医务人员血清中SARS冠状病毒抗体的存在情况。 结果 共调查SARS患者19例，血清中抗SARS冠状病毒抗体全部阳性；因工作需要与SARS患者或患者的血、尿、粪、痰等排泄物有接触的医务人员共200名，发现血清中抗SARS冠状病毒抗体阳性20例。 结论 在部分无症状医务人员血清中存在低水平的抗SARS冠状病毒IgG抗体，SARS冠状病毒感染可仅引起轻微的症状，甚至可无临床表现。

    Some medical staff positive for serum SARS coronavirus antibody IgG have only mild symptoms

    SI Jian-hua, TAN Jia-ju, YANG Guang, TANG Li-xia

    First People’s Hospital of Foshan City, Foshan 528000, China

    Abstract: Objective To identify patients with SARS coronavirus infection who have only mild symptoms. Method Enzyme-linked immunosorbent assay was employed to detect serum antibody against SARS coronavirus in the lysate of whole SARS coronavirus from 19 SARS patients and 200 medical staff members without obvious SARS symptoms after possible exposure to the virus during routine medical practice. Results Serum IgG antibody against SARS coronavirus was detected in all the 19 SARS patients, and among the 200 staff members, 20 (10%) were found positive for the antibody but with no obvious or only mild symptoms. Conclusion Serum IgG antibody against SARS coronavirus is positive in a small proportion (around 10%) of the medical staff members exposed to the virus in our hospital, but may not cause obvious symptoms, suggesting SARS coronavirus infection might in some cases have mild or even no clinical manifestations. ......