Expression of vascular endothelial growth factor receptor KDR in osteosarcoma and its relationship with microvessel density

    LIAO Bo1, MA Baoª²An1, LIU Zhe2, FAN Qingª²Yu1

    1Orthopedics Oncology Institute of Chinese PLA, Tangdu Hospital, Fourth Military Medical University, Xi¬ðan 710038, China, 2Institute of Meteria Medical, Administration of Scientific Research, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To explore the expression of vascular endothelial growth factor receptor (VEGFR) KDR and its relation with microvessel density(MVD). METHODS: CD34 and KDR were investigated in the specimens from 102 osteosarcoma patients. MVD was determined with double blind counting. RESULTS: KDR was strongly expressed in osteosarcoma cells, and weakly expressed in vascular endothelial cells. MVD was significantly different between KDR negative and positive groups (P<0.05). CONCLUSION: High expression of KDR may be related to oeteosarcoma. ......