摘要：目的 观察曲美他嗪对冠心病患者胰岛素抵抗的影响。 方法 将119例冠心病患者随机分为A、B两组。两组基本用药相同，B组另给曲美他嗪20 mg，3次/d，疗程8周。观察治疗前后血糖、胰岛素水平及胰岛素敏感指数的变化。 结果 B组与A组对比，治疗后空腹血胰岛素和服糖后2 h胰岛素降低(P<0.01)，胰岛素敏感指数增大(P<0.01)。 结论 曲美他嗪对冠心病伴胰岛素抵抗有一定的临床疗效。

    关键词：冠心病；曲美他嗪；胰岛素抵抗

    Effect of trimitazidine on insulin resistance in patients with coronary heart disease

    CAI Jian-sheng, PENG Zhi-jian

    Department of Cardiology, Second People's Hospital of Shantou, Shantou 515011, China

    Abstract: Objective To evaluate the efficacy of trimetazidine on insulin resistance in patients with coronary heart disease (CHD). Methods A cohort of 119 CHD patients were randomly divided in groups A and B receiving the same basic therapy, and the patients in group B were given additional trimetazidine 20 mg 3 times daily for 8 weeks. Before and after treatment, the changes in blood glucose, insulin levels and insulin sensitivity index were evaluated. Results The patients in group B showed better outcome than those in group A. After 8 weeks’ trimetazidine therapy, the fasting insulin and that 2 h after oral glucose were decreased (P<0.01), and the insulin sensitivity index was improved (P<0.01). Conclusion Trimetazidine may produce obvious therapeutic effect on insulin resistance in CHD patients. ......