Treatment of S180 tumor in mice with hyperthermia combined with chemotherapy

    LIU Xia1, SUN Cheng2, HUANG He2, DENG Jingª²Jing2, GUAN Jing2

    1Institute of Neurosciences of Chinese PLA, Fourth Military Medical University, Xi¬ðan 710033, China, 2Department of Radiology, General Hospital of Air Force, Beijing 100036, China

    ¡¾Abstract¡¿ AIM: To observe the antiª²tumor effect of hyperthermia combined with pharmorubicin on mice bearing S180 tumor. METHODS: Sixty mice bearing S180 tumor were equally divided into 4 groups randomly: group A treated with hyperthermia with pharmorubicin; group B with pharmorubicin therapy only;group C only with hyperthermia and group D as control group. The wet weight of tumor isolated from the mice and pathological changes were evaluated and compared after 10 days. RESULTS: The wet weight of tumor in group A¡¢B¡¢C and D was ((0.67¡À0.29)g¡¢(0.78¡À0.37)g¡¢(1.24¡À0.43)g and (2.31¡À0.22)g respectively. It was found that the wet weight of group A was less than that of the other three groups (P<0.01). Pathological observation showed the widespread necrosis in group A and group C. CONCLUSION: The hyperthermia combined with chemotherapy has a better antiª²tumor effect on mice bearing S180 tumor. It can be as adjuvant therapy for cancer. ......