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联合测定血清LDH、TPS、CEA和β2-MG对非霍奇金淋巴瘤的临床意义
http://www.100md.com 《南方医科大学学报》 2006年第2期
非霍奇金淋巴瘤,,非霍奇金淋巴瘤;乳酸脱氢酶;组织多肽特异性抗原;癌胚抗原;β2-微球蛋白摘要,目的,探讨在非霍奇金淋巴瘤(NHL)患者中,血清乳酸脱氢酶(LDH)、组织多肽特异性抗原(TPS)
     关键词: 非霍奇金淋巴瘤;乳酸脱氢酶;组织多肽特异性抗原;癌胚抗原;β2-微球蛋白

    摘要: 目的 探讨在非霍奇金淋巴瘤(NHL)患者中,血清乳酸脱氢酶(LDH)、组织多肽特异性抗原(TPS)、癌胚抗原(CEA)和β2-微球蛋白(β2-MG)4项指标测定的临床意义。方法 分别采用速率法和酶联免疫吸附法测定59例NHL患者及40例健康者血清LDH、TPS、CEA和β2-MG值。结果 NHL组血清LDH、TPS、CEA和β2-MG的水平高于健康组(P<0.05)。化疗后疗效评价为有效的患者化疗前的血清TPS、β2-MG水平高于化疗后(P<0.05),而化疗后疗效评价为有效的患者化疗前后的血清LDH、CEA水平无显著性差异(P>0.05).化疗后疗效评价为稳定、进展的患者化疗前后的血清LDH、TPS、CEA和β2-MG水平也无显著性差异(P>0.05)。结论 血清LDH、TPS、CEA和β2-MG水平可作为NHL患者诊断及疗效评估的辅助指标。

    Clinical value of combined detection of LDH, TPS, CEA and β2-MG in patients with non-Hodgkin’s lymphoma

    CHEN Wei, LUO Rong-cheng, FAN Wei-wen, MA Shu-dong

    Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

    Abstract: Objective To study the clinical value of combined detection of 4 tumor markers, namely lactic dehydrogenate (LDH), tissue polypeptide specific antigen (TPS), carcinoembryonic antigen (CEA) and β2-microglobulin (β2-MG) in patients with non-Hodgkin’s lymphoma (NHL). Methods The serum level of LDH is determined with automatic biochemical analyzer and TPS, CEA and β2-MG lvels are determined by enzyme-linked immumosorbent assay (ELISA) in 59 patients with NHL and 40 healthy adults. Results The levels of the 4 tumor markers were significantly higher in NHL patients than those in the healthy control subjects (P<0.05). After chemotherapy, the serum levels of TPS and β2-MG were significantly lowered in patients who showed favorable response to the treatment (P<0.05), but the levels of LDH and CEA did not change significantly (P>0.05). The serun levels of LDH, TPS, CEA and β2-MG in the patients with stable disease (SD) and progression (PD) did not undergo significant changes after chemotherapy (P>0.05). Conclusion Combined detection of LDH, TPS, CEA and β2-MG can be helpful to assist diagnosis of NHL and treatment evaluation. ......

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