胃癌组织中PTEN, MMP-9和Caspase-3表达的关系
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张丹丹, 郭 琳, 王 强
胃癌;PTEN;MMP-9;Caspase-3;免疫组织化学,胃癌组织中PTEN,MMP-9和Caspase-3表达的关系,张丹丹,郭琳,王强,通讯作者,RelationshipamongPTEN,m
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张丹丹, 中国医科大学附属第四医院胸外科 辽宁省沈阳市 110032
郭琳, 王强, 中国医科大学附属第二医院胃肠普通外科 辽宁省沈阳市 110004
张丹丹, 2001年牡丹江医学院本科毕业, 2005年中国医科大学附属第二医院普通外科硕士, 现从事胸外科临床工作.
通讯作者: 王强, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学附属第二医院胃肠普通外科. wangq@cmu2h.com
电话: 024-83955060
收稿日期: 2006-03-08 接受日期: 2006-03-25
Relationship among PTEN, matrix metalloproteinase-9, and Caspase-3 Expression in gastric carcinoma
Dan-Dan Zhang, Lin Guo, Qiang Wang
Dan-Dan Zhang, Department of Thoracic Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China
Lin Guo, Qiang Wang, Department of Gastroduodenal Surgery, the Second Affiliated Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Correspondence to: Dr. Qiang Wang, Department of Gastroduodenal Surgery, the Second Affiliated Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. wangq@cmu2h.com
Received: 2006-03-08 Accepted: 2006-03-25
Abstract
AIM: To study the expression of PTEN, matrix metalloproteinase-9 (MMP-9), and Caspase-3 in gastric cancer, and to discuss their roles and correlations in the occurrence, development, invasion and metastasis of gastric cancer.
METHODS: SP immunohistochemistry was used to measure the expression of PTEN, MMP-9, and Caspase-3 in 54 samples of gastric carcinoma selected from paraffin wax embodied specimens with complete clinicopathological data, and another 15 cases of normal gastric mucosa.
RESULTS: The expression of PTEN in gastric cancer was low (28/54, 51.9%), and reduced with the increased invasive depth (P = 0.004) and clinical stages (P = 0.001), reduced histological differentiation (P = 0.008) and occurrence of lymph node (P = 0.003) and long distance metastasis (P = 0.015). The expression of MMP-9 in gastric cancer was high (41/54, 75 ......
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