腹水/血清肿瘤标志物对良恶性腹水的鉴别价值
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黄家淼, 杨 剑, 周仁荣, 胡 健
腹水;良性;恶性;鉴别诊断;肿瘤标志物,黄家淼,杨剑,周仁荣,胡健,通讯作者,Valuesofsimultaneousdeterminationof5tum
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黄家淼, 杨剑, 周仁荣, 胡健, 中国人民解放军81医院消化科 江苏省南京市 210002
通讯作者: 黄家淼, 210002, 江苏省南京市太平南路34标34号, 中国人民解放军81医院消化科. hjmnj@sohu.com
电话: 025-80864047 传真：025-86648090
收稿日期: 2006-03-28 接受日期: 2006-04-13
Values of simultaneous determination of 5 tumor markers in fluid and serum and their ratio in differential diagnosis of benign and malignant ascites
Jia-Miao Huang, Jian Yang, Ren-Rong Zhou, Jian Hu
Jia-Miao Huang, Jian Yang, Ren-Rong Zhou, Jian Hu, Department of Gastroenterology, the 81st Hospital of Chinese PLA, Nanjing 210002, Jiangsu Province, China
Correspondence to: Jia-Miao Huang, Department of Gastroenterology, the 81st Hospital of Chinese PLA, 34-34 Taiping South Road, Nanjing 210002, Jiangsu Province, China. hjmnj@sohu.com
Received: 2006-03-28 Accepted: 2006-04-13
Abstract
AIM: To evaluate the values of the simultaneous determination of tumor markers AFP, CEA, CA19-9, CA50 and CA125 in fluid and serum, and their ratio (F/S) in the differential diagnosis of benign and malignant ascites.
METHODS: Serum and ascites fluid specimens were simultaneously collected from 105 patients with ascites (benign 57, malignant 48). The tumor markers AFP, CEA were determined by electrochemoluminescence. The tumor markers CA19-9, CA50 and CA125 were measured with radioimmunoassay (RIA).
RESULTS: The F/S ratios were all lower than 1.2 in benign ascites fluid and higher than 1.2 in the majority of malignant fluid when the tumor marker content in fluid was higher than the normal cut-off of serum (AFP > 25 μg/L, CEA > 5 μg/L, CA19-9 > 37 kU/L and CA50 > 20 mg/L). The combination of a F/S ratio greater than 1.2 and a cut-off stated above showed sensitivities of 18.8%, 62.5%, 58.3% and 72.9%, respectively for AFP, CEA, CA19-9 and CA50, with a specificity of 100%, These sensitivities were significantly higher than those of a single determination of concentration in fluid or F/S ratio (16 ......
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