川芎嗪__(期刊论文)

川芎嗪对癫痫大鼠大脑皮质及海马NOS表达的影响

http://www.100md.com 《咸宁学院学报(医学版)》 2005年第4期

川芎嗪,,川芎嗪；癫痫发作；一氧化氮合酶；青霉素；大鼠,1材料与方法,2结果,3讨论,参考文献：

     摘要:目的研究川芎嗪(TMP)对青霉素致痫大鼠大脑皮质及海马内一氧化氮合酶(NOS)表达的影响。方法使用青霉素致痫大鼠模型，采用BL410生物机能实验系统记录双侧大脑皮层痫样放电，观察腹腔注射(ip)TMP，对癫痫大鼠大脑皮质及海马内NOS表达的影响。结果腹腔注射TMP后，大脑皮质及海马内NOS的表达较对照组明显降低，差异具有显著性意义。结论 TMP能明抑制NOS的表达，具有抗癫痫作用。

    关键词：川芎嗪；癫痫发作；一氧化氮合酶；青霉素；大鼠

    The Effect of Tetramethylpyrazine on NOSExpression in Brain of Rats with Penicillininduced Epilepsy

    ZHU Xiaoqin,LEI Shuisheng,WEI Xianghong

    (Department of Physiology,Xianning College,Xianning Hubei 437100,China)

    ABSTRACT: Objective To study the influence of tetramethylpyrazine (TMP) on nitric oxide synthase(NOS ) expression in the cerebral cortex and hippocampus of rats with penicillineinduced epilepsy. Methods Making use of epilepsy model in rats by penicillin,using BL410 data acquistion analysis system to record the seizure like discharge from bilateral cerebral cortices.After injection (ip) with TMP, the changes of NOS immunoreaction in the cerebral cortex and hippocampus of rats were observed. Results After injection with TMP(ip), the expression of NOS in cerebral cortex and hippocampus greatly declined compared with the seizure group,(P<0.05). Conclusion TMP could have the function of restraining the seizure and significantly reduce the expression of NOS. ......

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