摘要：目的：探讨孕妇主动与被动联合免疫乙型肝炎病毒(HBV)宫内感染的作用和机理。方法：将106例HBsAg(+)孕妇分成两组，预防组60例，自孕妇20周起多次注射乙肝疫苗(HBVac)和乙肝免疫球蛋白(HBIG)；对照组46例，不用HBVac和HBIG。母婴血清HBsAg、HBeAg和 HBs用固相放免法检测，HBV-DNA用有套式PCR检测。结果：预防组新生儿血清HBsAg和HBV-DNA检出率明显低于对照组(3.3%)与26.1，10%与34.8%)均<0.05；预防组新生儿抗-HBs阳性率显著高于对照组(33.3%与8.7%)P<0.05。结论：孕妇于孕期通过HBIG和HBVac免疫，可有效预防HBV宫内感染，其机理可能为胎儿获得被动免疫。

    关键词： 乙型肝炎； 免疫球蛋白类； 肝炎疫苗

    Clinical Observation on Combination Immunization in Preventing Intrauterine HBV Infection

    ZHONG Na-lian

    (Chenxinghai Hospital of Zhongshan, Guangdong Zhongshan 528400, China)

    Abstract： Objective:To study the efficacy and possible mechanism of active and passive immunization during pregnancy in preventing intrauterine HBV infection.Method:Fifty three pregnant women with HBsAg positive were devided into two groups. In the prevention group,60 cases were injected with hepatitis B vaccine(HBVac)and hepatitis B immunoglobulin(HBIG) during pregnancy since the 20thweek of gestation) In the control group,46 cases without injec-tion of HBVac or HBIG. HBsAg ......