苄普地尔衍生物的合成
多药抗药性,,多药抗药性；苄普地尔衍生物；合成,1材料与方法,2结果,3讨论,参考文献:
摘要:目的 合成苄普地尔衍生物。方法 以异丙醇、环氧氯丙烷、哌啶为起始原料，反应中间体经二氯亚砜氯化后，与取代苯胺等缩合得到目标化合物。结果 设计并合成了6个苄普地尔衍生物。结论 6个衍生物均经红外光谱、核磁共振氢谱和质谱确证结构。关键词:多药抗药性；苄普地尔衍生物；合成
Synthesis of bepridil derivatives
PAN Ying,ZHANG Lumian,HE Xiaoying
(Department of Chemistry,Medical College of Shantou University,Shantou 515041,China)
Abstract: From readily available starting materials,isopropanol,epichlorohydrin and piperidine,six bepridil derivatives were synthesized via chlorination with SOCl2 and condensation with substituted anilines. The structures of the target compounds were elucidated on the basis of spectral data (IR,1H NMR and MS).
Key words:multidrug resistance; bepridil derivatives; synthesis
多药抗药性(multidrug resistance,MDR)是指肿瘤细胞接触一种天然性抗肿瘤药物并产生抗药性的同时,对结构和作用机理不同的其他多种天然性抗肿瘤药物产生交叉抗药性 ......
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