提高尼莫地平在注射液中溶解度的研究
尼莫地平,,尼莫地平；溶解度；注射乳剂,1材料与仪器,2实验部分,3讨论,参考文献
摘 要 目的 提高尼莫地平在注射液中的溶解度。方法 用正交设计试验优选尼莫地平注射乳剂的最佳工艺，将其与5%葡萄糖输液进行配伍试验。结果 用得到的最优处方制备的尼莫地平注射乳剂与葡萄糖输液配伍不产生沉淀。结论 尼莫地平注射乳剂具有良好的临床应用前景。关键词 尼莫地平；溶解度；注射乳剂
Solubility enhancement of nimodipine in parenteral solution
WANG Lin, CHEN Yanzhong, TANG Yi
(1. Department of Pharmaceutics, Guangdong Vocational and Technical College of Chemical Engineering Pharmacy, Guangzhou 510520, China; 2. Institute of Pharmaceutical Science, Guangdong College of Pharmacy, Guangzhou 510240, China)
Abstract Objective To increase the solubility of nimodipine in glucose solution. Methods The preparation method of emulsion was optimized with an orthogonal experiment. The compatibility of nimodipine and emulsion in 5% glucose solution was observed. Result and Conclusion Nimodipine emulsion was compatible with 5% glucose solution, thereby offering potential clinical benefits.
Key words nimodipine; solubility; emulsion injection
尼莫地平(nimodipine)是德国拜耳制药公司于20世纪80年代研制出来的第二代二氢吡啶类钙离子拮抗剂 ......
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