银杏内酯对犬脑血流量的影响
银杏,,],银杏；脑；局部血流,1材料与方法,2结果,3讨论,[参考文献]
[摘要] 目的：观察银杏内酯对犬脑血流量的影响。方法：将麻醉犬随机分为5组，每组4只，溶剂对照组灌胃食用油(1 ml/kg)，阳性药物对照组灌胃杏灵颗粒(0.22 g/kg)，受试药物各剂量组灌胃银杏内酯(分别为4.86、14.6、43.7 mg/kg)，给药后不同时间点分别记录颈内动脉血流量、血压、心电图、心率，并进行对照分析。结果：银杏内酯4.86、14.6、43.7 mg/kg灌胃，对麻醉犬血压、心率无显著影响；14.6及43.7 mg/kg灌胃90 min后使脑血流量显著增加， 43.7 mg/kg灌胃150 min后可显著减少脑血管阻力。结论：银杏内酯可降低麻醉犬脑血管阻力，增加脑血流量，不影响心率及血压。[关键词] 银杏；脑；局部血流
Effects of ginkgolide on cerebral blood flow in dogs
XU JiangPing, LI Lin, SUN LiSha
(Department of Pharmacology, First Military Medical University, Guangzhou, Guangdong Province 510515, China)
ABSTRACT Objective: To observe the effects of ginkgolide (GL) on the cerebral blood flow in dogs. Methods: Dogs anesthetized with sodium pentobarbital were randomly divided into 5 groups, with 4 dogs in each group. Ginkgolide of 4.86, 14.6 and 43.7 mg/kg and Xingling Granule of 0.22 g/kg were administered by gavage to the dogs in each of 4 groups. The dogs in the other group were administered with edible oil (1 ml/kg) as control group. The cerebral blood flow, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and electrocardiogram of the dogs were measured at different times after the administration. Results: Ginkgolide of 4.86, 14.6 and 43.7 mg/kg had no obvious effects on the blood pressure and the heart rate. Ginkgolide of 14.6 and 43.7 mg/kg increased the cerebral blood flow 90 minutes after administration, and ginkgolide of 43.7 mg/kg obviously decreased the cerebral vascular resistance 150 minutes after administration. Conclusion: Ginkgolide can increase the cerebral blood flow and decrease the cerebral vascular resistance, and it has no obvious effects on blood pressure and heart rate in dogs. ......
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