糖尿病肾病_____糖尿病肾病；对氧磷酯酶(PON)；活性

糖尿病肾病患者血清PON活性变化及其临床意义

http://www.100md.com 《广东药学院学报》 2003年第2期

糖尿病肾病,,糖尿病肾病；对氧磷酯酶(PON)；活性,1受试对象,2方法,3结果,4讨论

     摘要目的：探讨对氧磷酯酶(PON)活性变化与糖尿病肾病(DN)的关系。方法：分光光度法检测实验对象血清PON活性；放免法检测血清免疫反应性胰岛素(IRI)、C肽(CP)水平。结果：DN患者、2型糖尿病患者(T2D)、正常对照者血清PON活性平均值呈上升趋势，即PON活性按以下顺序增高：DN0.05; r=0.138 P>0.05)，而与血清低密度脂蛋白成负相关(r=-0.159,P<0.05)。Logistic回归分析表明：PON活性(P<0.001, 模型总判对率93.7%)、LDL(P<0.001，模型总判对率89.4%)是DN的独立变异危险因素。结论：PON活性变化与DN的发病有关1。

    关键词糖尿病肾病；对氧磷酯酶(PON)；活性

    Association of paraoxonase activity with diabetic nephropathy

    HAO Yunling,LIN Lixiang, CHEN Gang, HE Zhenyu

    (1. Department of Internal Medicine, Guangdong College of Pharmacy, Guangzhou 510224; 2. Department of Endocrinology, Fujian Provincial Hospital, Fuzhou 350001)

    Abstract Objective：To investigate the association of the variation of paraoxonase (PON) activity with Diabetic Nephropathy (DN), and the pathogenesis of DN. Methods: PON activity was determined with spectrophotography in DN patients, type II diabetes (T2D) patients and healthy volunteers as the control group. Serum immune-reactive insulin (IRI) and C-peptides (C-P) were measured with radioimmunoassay method. Results: PON activities in DN patients, T2D patients, and healthy volunteers increased in the sequence of DN0.005; r=0.138, P>0.005), however, it was correlated with serum LDL (r=-0.159, P<0005). Logistic regression analysis suggested that PON activity (P<0.001)and LDL (P<0.001) were the independent risk factors of DN. Conclusion: PON activity is associated with the pathogenesis of DN. ......

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