【摘要】 目的 探讨三种纤维蛋白原(Fib)测定方法的临床应用价值。方法 用免疫比浊法、PT衍算法(PT-der)、克劳斯(Von claus)法测定低、中、高值血清的纤维蛋白原含量，并进行比较。结果 免疫比浊法结果与PT-der法、克劳斯法相比有明显的差异(P<0.05)。PT-der法和克劳斯法对样本的测定具有在Fib含量在2～4g/L时测定结果无统计学差异(P>0.05)，在Fib>4g/L和Fib<2g/L时差异均有显著性(P<0.05)。结论 建议在临床实验室尽快采用准确、快速和简便的克劳斯法测定纤维蛋白原含量。

    【关键词】 纤维蛋白原；免疫比浊法；PT-der法；克劳斯法

    Evaluation of three methods for fibrinogen detection

    WANG Qiao-lian.The Fourth Hospital of Baotou City,Neimeng 014030,China

    【Abstract】 Objective To evaluate 3 methods for fibrinogen detection.Methods Immunoturbidimetry , PT-der method and von Klaus method were used to determine fibrinogen in high-, middle- and low- value plasma samples and compared their results.Results Immunotubidimetry had significant difference (P<0.05) comparing to PT-der method and von Klaus method. When the content of fibrinogen was 2-4g/L, there was no significant difference between the PT-der method and von Klaus method (P>0.05). However, there was marked difference between these 2 methods when fibrinogen content was lower than 2g/L or over 4g/L(P<0.05).Conclusion von Klaus method is more accurate, faster and simpler and should be of first choice for laboratory test of fibrinogen. ......