多药耐药基因蛋白在贲门癌组织中的表达及其临床价值
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史宏灿, 石维平, 束余声, 陆世春, 王 康,
贲门癌;多药耐药;P-糖蛋白;谷胱甘肽S-转移酶;拓朴异构酶-Ⅱ;肺耐药相关蛋白史宏灿,石维平,束余声,陆世春,王康,顾学文,田秀春.多药耐药基因蛋白在贲门癌组织中的表达及其临床意义. 世
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史宏灿, 石维平, 束余声, 陆世春, 王康, 扬州大学临床医学院胸心外科 江苏省扬州市 225001
顾学文, 田秀春, 扬州大学临床医学院病理科 江苏省扬州市 225001
史宏灿, 2003年第二军医大学博士研究生毕业, 副教授, 副主任医师, 主要从事胸部肿瘤的基础与外科临床研究.
通讯作者: 史宏灿, 225001, 江苏省扬州市南通西路98号, 扬州大学临床医学院胸心外科. shcan111@yahoo.com.cn
收稿日期: 2006-03-15 接受日期: 2006-04-06
Expression of P-glycoprotein, glutathione S-transferase-π, topoisomerase Ⅱ and lung resistance protein in cardiac carcinoma and their clinical significances
Hong-Can Shi, Wei-Ping Shi, Yu-Cheng Shu, Shi-Chun Lu, Kang Wang, Xue-Wen Gu, Xiu-Chun Tian
Hong-Can Shi, Wei-Ping Shi, Yu-Sheng Shu, Shi-Chun Lu, Kang Wang, Department of Cardiothoracic Surgery, Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Xue-Wen Gu, Xiu-Chun Tian, Department of Pathology, Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Correspondence to: Hong-Can Shi, Department of Cardiothoracic Surgery, Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China. shcan111@yahoo.com.cn
Received: 2006-03-15 Accepted: 2006-04-06
Abstract
AIM:To investigate the expression of multidrug resistant proteins and their clinical significances in cardiac carcinoma tissues.
METHODS:The expression of P-glycoprotein (P-gp), glutathione S-transferase-p (GST-p), topoisomerase Ⅱ (Topo-Ⅱ) and lung resistance protein (LRP) in 69 patients with cardiac carcinoma were determined by SP immunohistochemistry,and the results were studied in correlation with clinicopathological data.
RESULTS:The positive rates of P-gp, GST-p, Topo-Ⅱ and LRP expression in cardiac carcinoma (49.2%, 75.4%, 68.1% and 58%, respectively) were all higher than those in the normal tissues (0, 30%, 20% and 0, respectively, all P < 0.01). The expression of P-gp was correlated with clinical staging (Ⅰ,Ⅱ vs Ⅲ,Ⅳ: 28.6% vs 58.3%, P < 0.05) and lymphatic metastasis (metastasis vs non-metastasis: 67 ......
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