摘 要

    目的：探讨乙肝患者体内遗传物质的损伤情况。方法：选择正常对照组20例，单纯HBsAg(+)增高组16例，乙肝组16例，乙肝恢复组10例，HBsAg、抗HBe、抗HBc三阳组12例，脂肪肝组16例，做孕早期绒毛姐妹染色单体交换(SCE)率的检测。结果：单纯HBsAg(+)增高组、乙肝组自发和诱发SCE逐步增高，且与对照组间均有显著差异；乙肝恢复组较乙肝组SCE下降；其他肝病患者较乙肝组SCE均较低。结论：乙肝妊娠妇女体内出现DNA损伤及修复功能障碍。

     关键词 乙肝；孕早期；绒毛；姐妹染色单体交换

    中图分类号 R512.6+2

    The Study on Chorion Sister Chrimatid Exchange (SCE) Rate of the Early Pregnant

    Women with Hepatitis B

    YUE Shufen,SANG Fang,ZHAO Ziwei,HAO Fen

    (Baotou Medical College,Baotou 014010,China)

    Abstract Objective: To investigate the damage extent of germ plasm in the patients with hepatitisB. Methods: To detect the chorion SCE rate of the control groups, including 20 normal pregnant women,Group 1 of 16 with increased HBsAg, Group 2 of 16 with hepatitisB, Group 3 of 10 with recovered hepatitis B, Group 4 of 12 with HBsAg(+), HBeAb(+), HbcAb(+) and Group 5 of 16 with fatty liver. Results: Spontaneous and induced SCE rate increased graduallyin control group, Group 1 and Group 2. At the same time, there were significantly differences among the three groups. In Group 3 and the other two groups, SCE rate all decreased. Conclusion: DNA damnification and repair obstruction appeared in the pregnant women with hepatitis B. ......