Longª²term effects of cilostazol on clinical outcomes after coronary stent implantation in smallª²vessel lesions

    WANG Shouª²Li, HAN Yaª²Ling, JING Quanª²Min, WANG Zuª²Lu, WANG Dongª²Mei, DENG Jie, YANG Guiª²Tang, YU Haiª²Bo

    PLA Institute of Cardiovascular Research, General Hospital, Shenyang Military Command, Shenyang 110016, China

    ¡¾Abstract¡¿ AIM: To evaluate the effects of cilostazol on smallª²vessel lesions and longª²term clinical outcomes in patients receiving coronary stent implantation. METHODS: One hundred and ninetyª²three patients who had underwent coronary stenting were randomly assigned to two groups after operation. Ninetyª²eight patients who had been taking aspirin 100 mg/d were given clopidogrel treatment 75 mg/d for 3 months in control group and 95 patients were given clopidogrel treatment 75 mg/d for 3 months plus cilostazol 200 mg/d for 6 months in treatment group. Angiographic followª²up was carried out at 6 months and clinical followª²up at 1 year after stenting. RESULTS: Angiographic restenosis occurred in 12 of the 53 patients (23%) in the treatment group and 17 of 52 patients (33%) in the control group (P>0.05). By the end of 1 year followª²up after operation, no difference was found in the rates of readmission due to cardiac and cerebral vascular diseases and no difference was found in the sideª²effects of drugs such as hemorrhage between the two groups. CONCLUSION: Cilostazol treatment after PCI is safe and the treatment with cilostazo can decrease the rate of restenosis. ......