血管抑制素类_____血管抑制素类；188Re；同位素标记

188Re血管抑素的制备及其在小鼠体内分布

http://www.100md.com 《第四军医大学学报》 2005年第12期

血管抑制素类,,血管抑制素类；188Re；同位素标记,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Preparation of 188ReAS and its distribution in mice

    ZHANG XiaoHui1, XU HaiFeng1,CHENG ShiWu2

    1Department of Nuclear Medicine, Tangdu Hospital , Fourth Military Medical University, Xian 710038, China, 2Department of Nuclear Medicine, Xijing Hospital , Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM： To explore the method of 188Re direct labeling of angiostatin (AS) and investigate the stability of 188ReAS in vitro and its distribution in mice.METHODS: AS was synthesized, validated, then labeled with 188Re after being reduced by SnCl2. Labeling efficiency was measured by paper chromatography. The stability of 188ReAS was observed when BSA, saline and different molar ratios of Cys: AS was added separately. RESULTS: The labeled efficiency can reach 763% for the SnCl2reduced approach. The best experimental condition was described below: AS100 μg，20 g/L SnCl2 (dissolved in 1 mol/L hydrochloric acid)200 μL, 01 mol/L sodium tartrate (dissolved in 005 mol/L hydrochloric acid), and then 188ReO437 MBq was added. There was high liver and kidney uptake and the radiotracer excreted through renal. CONCLUSION: 188Re direct labeling of AS is simple and efficient. 188ReAS is stable in vitro. ......

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