生肌化瘀方_____]_生肌化瘀方;

生肌化瘀方及其拆方对大鼠创面修复早期肉芽组织中Ⅰ、Ⅲ型胶原的影响

http://www.100md.com 《中西医结合学报》 2005年第3期

生肌化瘀方,,],生肌化瘀方;,创面修复;,肉芽组织;,Ⅰ型胶原;,Ⅲ型胶原,1材料与方法,2结果,3讨论,[参考文献]

     [摘要] 目的：探讨生肌化瘀方及其拆方对创面修复早期Ⅰ、Ⅲ型胶原的影响。方法：将24只清洁级雄性SD大鼠随机分为4组：生肌化瘀方组、生肌方组、化瘀方组和模型组。以大鼠皮肤全层缺损创面为模型，采用免疫组化和图像分析相结合的方法，观察各组大鼠创面修复早期肉芽组织中Ⅰ、Ⅲ型胶原的变化。结果：在创面修复的第3天，生肌方组和生肌化瘀方组的Ⅰ型胶原水平均高于模型组，化瘀方组则低于模型组(P <0.05)；生肌方组、化瘀方组和生肌化瘀方组的Ⅲ型胶原水平均低于模型组(P<0.05)，以化瘀方组更为明显；在创面修复的第7天，生肌方组、生肌化瘀方组的Ⅰ型胶原水平均低于模型组(P<0.05)；生肌方组和化瘀方组的Ⅲ型胶原水平均高于模型组(P<0.05)。结论：祛瘀生肌法可以促进大鼠创面修复，减少瘢痕形成。

    [关键词] 生肌化瘀方; 创面修复; 肉芽组织; Ⅰ型胶原; Ⅲ型胶原

    Effects of Shengji Huayu Recipe and its decomposed formulas on synthesis of collagen types Ⅰ and Ⅲ in granulation tissue of rats in early wound healing

    LI Bin, WANG ZhenYi, XIAO XiuLi, LI FuLun, FAN Bin

    (Department of Chinese Traditional Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China)

    ABSTRACT Objective:To study the effects of Shengji Huayu Recipe (a traditional Chinese medicine compound recipe for resolving stagnation and promoting granulation) and its decomposed formulas (Huayu Recipe for resolving stagnation and Shengji Recipe for promoting granulation) on the synthesis of collagen types Ⅰ and Ⅲ in granulation tissue of rats in early wound healing. Methods: Twentyfour male SpragueDawley (SD) rats with fullthickness skin lesion were randomized into 4 groups: Shengji Huayu Recipetreated group, Shengji Recipetreated group, Huayu Recipetreated group and untreated group. Collagen types Ⅰ and Ⅲ in granulation tissue of the rats were tested with immunohistochemical methods and image analysis. Results: On the third day of wound healing, collagen Ⅰ of the rats in both Shengji Huayu Recipetreated group and Shengji Recipetreated group was higher than that in the untreated group, and collagen Ⅰ of the rats in Huayu Recipetreated group was lower than that in the untreated group (P<0.05). Collagen Ⅲ of the rats in the three treated groups were lower than that in the untreated group (P<0.05). On the seventh day of wound healing, Collagen Ⅰ of the rats in both Shengji Huayu Recipetreated group and Shengji Recipetreated group was higher than that in the untreated group (P<0.05), and collagen Ⅲ of the rats in both Shengji Recipetreated group and Huayu Recipetreated group was higher than that in the untreated group (P<0.05). Conclusion: Resolving stagnation and promoting granulation therapy can promote the wound healing in rats. ......

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