【摘要】 目的 探讨尼莫地平对大鼠急性脑缺血再灌注损伤的保护作用。方法 将局灶性缺血模型大鼠分为假手术组、缺血组及尼莫地平干预组,测各组大鼠脑组织亚细胞器丙二醛(MDA)、超氧化物歧化酶(SOD)的含量及脑细胞内游离Ca2+浓度。结果 脑缺血再灌注后脑组织MDA及Ca2+浓度显著升高,SOD显著降低。尼莫地平能改善这种状况。结论 尼莫地平对急性脑缺血再灌注损伤有保护作用,其机制与降低脑细胞MDA、Ca2+浓度升高SOD有关。

    【关键词】 尼莫地平 脑缺血再灌注损伤 氧自由基 钙离子浓度

    The Protective Effects of Nimodipine on Acute Cerebral Ischemic Reperfusion Injury in the Rats Yang Yuting,et al. (Surgical Department General Remarks Lab,Xingxiang Medical College,He’nan 453003)

    【Abstract】 Objective To study the protective effects of nimodipine on acute cerebral ischemic reperfusion injury in the rats.Methods The animal model obtained by occluding the left middle cerebral artery.Then measured the level of MDA、SOD、VitE.Results In the ischemic reperfusion group,MDA increased and SOD VitE decreased significantly in the cerebral subcellular organ.Nimodipine could improve these conditions.Conclusions Nimodipine can protect the cerebral ischemic injury by decreasing MDA and increase SOD、VitE in the subcellular organ. ......