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利脑宁镇静催眠作用的实验研究
http://www.100md.com 《第四军医大学学报》 2006年第10期
利脑宁,,利脑宁;复方;催眠药和镇静药,【摘要】,【关键词】,0引言,1材料和方法,2结果,3讨论,【参考文献】
     Experimental studies on sedativehypnotic effect of Linaoning

    SHI LiXia, ZHANG ZhenJia

    Department of Pharmacy, Affiliated Hospital, Jilin Medical College, Jilin 132013, China

    【Abstract】AIM: To study the sedativehypnotic effect of Linaoning(LNN) (a complex prescription of traditional Chinese medicine ), and provide an experimental base and a theoretical foundation for its clinical application. METHODS: The sedativehypnotic effect was studied by observing the spontaneous action and pentobarbital sleeping time in mice. RESULTS: LNN obviously decreased the walking time and the frequence of its raising forelimb. Compared with preadministration or control group, lowdose LNN (P<0.05), middle and highdoseLNN (P<0.01) obviously prolonged the pentobarbital sleeping time in mice in a dosedependent manner. CONCLUSION: LNN does have the sedativehypnotic effect.

    【Keywords】 LINAONING, compounds, hypnotics and sedatives

     【摘要】 目的: 研究中药复方制剂利脑宁(LNN)的镇静催眠作用,为该药的临床应用提供实验依据. 方法: 采用小鼠自发活动、戊巴比妥钠睡眠时间的研究方法 ......

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