Preventive effect of tartarian buckwheat shell extract on fatty liver induced by highª²lipid diet in rats

    TONG Hongª²Li, TIAN Yaª²Ping, WANG Deª²Qing, DONG Zhenª²Nan, DENG Xinª²Xin

    Department of Clinical Biochemistry, Chinese PLA General Hospital, Beijing 100853, China

    ¡¾Abstract¡¿ AIM: To investigate the preventive effect of tartarian buckwheat shell extract (TBSE) on fatty liver induced by highª²lipid diet in rats and it mechanism. METHODS: Fifty male Wistar rats were randomly separated into 5 groups according to body weight. They were fed with normal diet, highª²lipid diet, highª²lipid diet supplemented with different concentrations of TBSE (0.825 g/kg, 0.165 g/kg), highª²lipid diet supplemented with Lipingzhi capsules (LPZ, 0.067 g/kg), respectively. After 12 weeks, in liver tissues, Ch, Tg, MDA concentrations, SOD, GPX activities were measured, and the histological changes were observed. RESULTS: Compared with normal diet group, in highª²lipid diet group liver Ch, Tg, MDA concentrations increased significantly (P<0.01); liver SOD activity decreased significantly (P<0.01); liver GPX activity decreased, but there was no significantly statistical difference (P>0.05). Compared with high lipid diet group, in TBSE groups, liver Ch concentration decreased significantly (P<0.05), liver SOD activity increased significantly (P<0.05), and liver GPX activity increased, but there was no significantly statistical difference (P>0.05); in highª²dose TBSE group, liver Tg, MDA concentration decreased significantly (P<0.05); in lowª²dose TBSE group, liver Tg, MDA concentration decreased, but there was no significantly statistical difference (P>0.05). In LPZ group, compared with highª²lipid diet group, liver Ch concentration, GPX activity decreased significantly (P<0.05); liver MDA, Tg concentration, SOD activity had no significantly statistical changes (P>0.05). CONCLUSION: TBSE could decrease liver Ch, Tg concentration, reduce liver lipid deposition and lipid peroxidation, increase liver antioxidant activity in rats with hyperlipidemia, which could protect hepatocytes from fatty degeneration. ......