结扎和硬化疗法治疗肝硬化食管静脉曲张出血疗效比较的荟粹分析
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范铁艳, 程留芳
硬化;套扎;肝硬化;食管静脉曲张出血;荟萃分析,范铁艳,程留芳,范铁艳,通讯作者,Comparisonbetweeneffectsoflig
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范铁艳, 程留芳, 中国人民解放军总医院 消化内科 北京市 100853
范铁艳, 住院医师, 2005级解放军军医进修学院博士生, 从事肝硬化食管静脉曲张的基础与临床研究.
通讯作者: 范铁艳, 100853, 北京市, 中国人民解放军总医院消化科. fantieyan2006@163.com
电话: 010-66937078
收稿日期: 2006-04-05 接受日期: 2006-04-16
Comparison between effects of ligation and sclerotherapy in treatment of esophageal variceal bleeding after liver cirrhosis: a meta-analysis
Tie-Yan Fan, Liu-Fang Cheng
Tie-Yan Fan, Liu-Fang Cheng, Department of Gastroenterology, General Hospital of Chinese PLA, Beijing 100853, China
Correspondence to: Tie-Yan Fan, Department of Gastroenterology, General Hospital of Chinese PLA, 100853 Beijing, China. fantieyan2006@163.com
Received: 2006-04-05 Accepted: 2006-04-16
Abstract
AIM: To systematically evaluate the therapeutic effect of endoscopic injection sclerotherapy (EIS) and endoscopic variceal ligation (EVL) on esophageal variceal bleeding after liver cirrhosis.
METHODS: The correlated literature about the therapeutic effect of EIS and EVL on esophageal variceal were identified from Medline, EMBase and China Biological Medicine Disk between January, 1985 and November, 2005. RevMan 4.2.8 software was used for data analysis.
RESULTS: According to the included criteria, seven prospective, randomized, controlled, clinical trials were selected finally. The combined results of meta-analysis showed that the rehaemorrhage rate of scherotherapy on the esophageal variceal bleeding after liver cirrhosis was higher than ligation (RR = 1.32, 95%CI: 1.10-1.57, P < 0.05), while their motility rates were similar (RR = 1.24, 95%CI: 0.99-1.55, P > 0.05).
CONCLUSION: In comparing with EIS, EVL has a better effect on obviating rehaemorrhage in esophageal varices bleeding after liver cirrhosis but has no difference in degrading motility.
Key Words: Ligation; Sclerotherapy; Liver cirrhosis; Esophageal variceal bleeding; Meta-analysis ......
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