苦参碱对大鼠原位肝移植冷缺血再灌注损伤的保护作用
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朱新华, 仇毓东, 史敏科, 丁义涛
原位肝移植;苦参碱;缺血再灌注损伤;内皮细胞;大鼠,朱新华,仇毓东,史敏科,丁义涛,朱新华,通讯作者,Effectsofmatrineoncoldis
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朱新华, 仇毓东, 史敏科, 丁义涛, 南京大学医学院附属鼓楼医院肝胆外科 江苏省南京市 210008
朱新华, 2003年南京大学博士, 主治医师, 主要从事肝脏移植及原发性肝癌的临床和基础研究工作.
江苏省中医药管理局资助项目, No. SZ9902
通讯作者: 仇毓东, 210008, 江苏省南京市, 南京大学医学院附属鼓楼医院肝胆外科. yudongqiu510@hotmail.com
电话: 025-83304616 传真: 025-83317016
收稿日期: 2006-04-23 接受日期: 2006-05-11
Effects of matrine on cold ischemia and reperfusion injury during orthotopic liver transplantation in rats
Xin-Hua Zhu, Yu-Dong Qiu, Min-Ke Shi, Yi-Tao Ding
Xin-Hua Zhu, Yu-Dong Qiu, Min-Ke Shi, Yi-Tao Ding, Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu Province, China
Supported by the Traditional Chinese Medicine Administration Bureau of Jiangsu Province, No. SZ9902
Correspondence to: Dr. Yu-Dong Qiu, Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu Province, China. yudongqiu510@hotmail.com
Received: 2006-04-23 Accepted: 2006-05-11
Abstract
AIM: To investigate the protective effect of matrine on the cold ischemia and reperfusion (I/R) injury during orthotopic liver transplantation (OLT) and its mechanism in rats.
METHODS: Two hundred and twenty-four syngeneic SD rats were randomly divided into control, matrine, and pseudo-treatment group. The rats in matrine group were treated with low (40 mg/kg) and high dose (80 mg/kg) of matrine respectively. After the donor liver was preserved in Ringer’s (LR) solution for 5 h, the orthotopic implantation was performed. The serum and tissue samples were collected for analysis 1, 2, 4 and 24 h after reperfusion of the portal vein, and the one-week survival rate was observed in each group.
RESULTS: In comparison with those in the control group, the levels of ALT decreased significantly in low- and high-dose treatment groups at different times post-transplantation, and their one-week survival rates also increased markedly (75%, 75% vs 0, P < 0 ......
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