大鼠急性胰腺炎早期肺损伤机制及前列腺素E1的保护作用
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尹 勇, 李兆丽
急性胰腺炎;肺损伤;前列腺素E1;细胞间黏附分子-1;中性粒细胞;氧自由基,大鼠急性胰腺炎早期肺损伤机制及前列腺素E1的保护作用,尹勇,李兆丽,通讯作者,Mechanismoflunginjuryan
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尹勇, 苏州大学附属第三医院普外科 江苏省常州市 213003
李兆丽, 苏州大学附属第三医院病理科 江苏省常州市 213003
尹勇, 2004年中山大学附属第一医院博士研究生毕业, 主治医师, 主要从事胃肠胰疾病的研究.
通讯作者: 尹勇, 213003, 江苏省常州市局前街185号, 苏州大学附属第三医院普外科. yinyong1973@163.com
电话: 0519-6180071
收稿日期: 2006-02-27 接受日期: 2006-05-08
Mechanism of lung injury and protective effect of prostaglandin E1 in experimental acute pancreatitis
Yong Yin, Zhao-Li Li
Yong Yin, Department of General Surgery, the Third Affiliated Hospital of Suzhou University, Changzhou 213003, Jiangsu Province, China
Zhao-Li Li, Department of Pathology, the Third Affiliated Hospital of Suzhou University, Changzhou 213003, Jiangsu Province, China
Correspondence to: Yong Yin, Department of General Surgery, the Third Affiliated Hospital of Suzhou University, 185 Juqian Street, Changzhou 213003, Jiangsu Province, China. yinyong1973@163.com
Received: 2006-02-27 Accepted: 2006-05-08
Abstract
AIM: To explore the mechanism of lung injury in experimental acute pancreatitis (AP) and the protective effect of prostaglandin E1 (PGE1).
METHODS: Seventy-eight rats were averagely and randomly divided into sham operation, AP, and PGE1 group. AP model was induced by creating a closed duod enal loop in rats. The rats in PGE1 group were intravenously injected with PGE1 (60 ng/kg). The histopathological changes of pancreatic and pulmonary tissues were examined by microscopy. The serum level of amylase, the activity of myeloperoxidase (MPO), the pulmonary level of lipid peroxidation (LPO), and lung capillary permeability (LCP) were measured. The expression of pulmonary intercellular adhesion molecule-1 (ICAM-1) was determined by immunohistochemical technique (ABC).
RESULTS: In AP group, the progressive pathological damages in the pancreas and lung tissues were clearly observed ......
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