拉米夫定体外对慢性乙型肝炎患者树突状细胞功能的影响
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张冬云, 郑鹏远, 张晓琴, 刘光辉, 娄惠萍,
慢性乙型肝炎;树突状细胞;抗原提呈;拉米夫定,张冬云,郑鹏远,张晓琴,刘光辉,娄惠萍,唐芙爱,白经修,祁元明,张冬云,Invitroeffectso
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张冬云, 郑鹏远, 张晓琴, 刘光辉, 娄惠萍, 唐芙爱, 白经修, 祁元明, 郑州大学第二附属医院消化内科 河南省郑州市 450052
张冬云, 1999年河南医科大学临床医学学士, 2003年郑州大学医学院硕士, 主要从事慢乙肝的基础研究.
河南省医学科技创新人才工程基金资助项目, No. 2004-45
通讯作者: 郑鹏远, 450014, 河南省郑州市经八路2号, 郑州大学第二附属医院消化内科. medp7123@yahoo.com
电话: 0371-65261035
收稿日期: 2006-04-01 接受日期: 2006-04-20
In vitro effects of lamivudine on function of dendritic cells derived from patients with chronic hepatitis B infection
Dong-Yun Zhang, Peng-Yuan Zheng, Xiao-Qin Zhang, Guang-Hui Liu, Hui-Ping Lou, Fu-Ai Tang, Jing-Xiu Bai, Yuan-Ming Qi
Dong-Yun Zhang, Peng-Yuan Zheng, Xiao-Qin Zhang, Guang-Hui Liu, Hui-Ping Lou, Fu-Ai Tang, Jing-Xiu Bai, Yuan-Ming Qi, Department of Digestive Disease, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, Henan Province, China
Supported by the Medical Science and Technology Innovation Talent Project of Henan Province, No. 2004-45
Correspondence to: Dr. Peng-Yuan Zheng, The Department of Digestive Disease, The Second Affiliated Hospital of Zhengzhou University, 450014, 2 JingBa Rd, Zhengzhou, China. medp7123@yahoo.com
Received: 2006-04-01 Accepted: 2006-04-20
Abstract
AIM: To investigate the effects of lamivudine on the function of dendritic cells derived from patients with chronic hepatitis B (CHB) in vitro.
METHODS: Dentritic cells (DCs) derived from the monocytes of CHB patients were cultured with interleukin-4 (IL-4) plus granulocyte-macrophage colony-stimulating factor (GM-CSF). Three days after being cultured, the cells were divided group A and B. Group A was treated with different concentrations of lamivudine (0, 0.125, 0.25, 0.5, 1, 2 mmol/L), while group B served as the control. Cell morphology was observed under light microscope and cell surface molecules including HLA-DR, CD80, CD83, and CD1a were assayed by flow cytometry. The concentrations of IL-6 and IL-12 in the supernatant were measured by enzyme-linked immunosorbent assay (ELISA) ......
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